Scientists identify new cancer stem cell mechanism

Public release date: 27-Jun-2012
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Contact: Bridget Dempsey
b.dempsey@qmul.ac.uk
44-207-882-7927
Queen Mary, University of London

Scientists at Queen Mary, University of London have uncovered a link between two genes which shows how stem cells could develop into cancer.

The research, published in the online journal PLoS ONE, found a novel mechanism which could be the catalyst for stem cells changing into a tumour.

Dr Ahmad Waseem, a reader in oral dentistry at Queen Mary, University of London who led the research, said: "It was quite an unexpected discovery. We set out to investigate the role of the stem cell gene Keratin K15 which was thought to be a biomarker for normal stem cells.

"Through our research, we discovered there was link between K15 and the notorious cancer gene FOXM1. We found FOXM1 could target K15 to induce cancer formation."

Cancer develops when there is a problem with stem cells; the cells that carry out internal repairs throughout the human body. The loss of stem cell function leads to uncontrolled growth which ultimately develops into a tumour.

The team went through a process where they used extremely sensitive cell and molecular approaches to establish this link.

The study, funded by the Facial Surgery Research Foundation, Saving Faces, paves the way towards identifying new anti-cancer drugs which could be tailored towards cancer stem cells.

Consultant oral and maxillofacial surgeon Professor Iain Hutchison, founder of Saving Faces and co-author on the study, said: "We are excited about this finding as it could lead to more effective cancer drugs being developed to target cancer stem cells and prevent cancer recurrence."

###

'Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling' will be published online in the journal PLoS ONE at 17.00 (EST) on 27 June. A link to the article can be found here: http://dx.plos.org/10.1371/journal.pone.0038599

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 27-Jun-2012
[ | E-mail | Share ]

Contact: Bridget Dempsey
b.dempsey@qmul.ac.uk
44-207-882-7927
Queen Mary, University of London

Scientists at Queen Mary, University of London have uncovered a link between two genes which shows how stem cells could develop into cancer.

The research, published in the online journal PLoS ONE, found a novel mechanism which could be the catalyst for stem cells changing into a tumour.

Dr Ahmad Waseem, a reader in oral dentistry at Queen Mary, University of London who led the research, said: "It was quite an unexpected discovery. We set out to investigate the role of the stem cell gene Keratin K15 which was thought to be a biomarker for normal stem cells.

"Through our research, we discovered there was link between K15 and the notorious cancer gene FOXM1. We found FOXM1 could target K15 to induce cancer formation."

Cancer develops when there is a problem with stem cells; the cells that carry out internal repairs throughout the human body. The loss of stem cell function leads to uncontrolled growth which ultimately develops into a tumour.

The team went through a process where they used extremely sensitive cell and molecular approaches to establish this link.

The study, funded by the Facial Surgery Research Foundation, Saving Faces, paves the way towards identifying new anti-cancer drugs which could be tailored towards cancer stem cells.

Consultant oral and maxillofacial surgeon Professor Iain Hutchison, founder of Saving Faces and co-author on the study, said: "We are excited about this finding as it could lead to more effective cancer drugs being developed to target cancer stem cells and prevent cancer recurrence."

###

'Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling' will be published online in the journal PLoS ONE at 17.00 (EST) on 27 June. A link to the article can be found here: http://dx.plos.org/10.1371/journal.pone.0038599

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-06/qmuo-sin062612.php

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What Is Acute Myelogenous Leukemia, the Cancer That Struck Nora Ephron?

Ask the Experts | Health

The When Harry Met Sally screenwriter recently succumbed to this enigmatic form of cancer, but there are new treatments in the pipeline

By Larry Greenemeier ?| June 28, 2012

BRAVE FACE: Nora Ephron at the 2010 Tribeca Film Festival. She was first diagnosed in 2006 with a type of myelodysplastic syndrome (MDS), a category of blood diseases also referred to as "preleukemia." This later progressed to acute myeloid leukemia (AML). Image: Courtesy of David Shankbone, via Wikimedia Commons

Nora Ephron's final act played out in Manhattan on June 26 where the 71-year-old writer and movie director died from pneumonia brought on by acute myeloid leukemia (AML), one of the most common types of leukemia among adults. AML is a cancer caused when abnormal cells grow inside bone marrow and interfere with the production of healthy blood cells. The marrow eventually stops working correctly, leaving a person with an increased risk of bleeding and infections.

Ephron?best known for writing When Harry Met Sally and Sleepless in Seattle?was first diagnosed in 2006 with one of the myelodysplastic syndromes (MDS), a category of blood diseases also referred to as "preleukemia" that can progress into AML if the bone marrow continually fails to produce enough healthy platelets, red blood cells and white blood cells over time. MDS made headlines recently when ABC's Good Morning America anchor Robin Roberts announced she has been diagnosed with the disease.

Some types of leukemia, including AML, develop as a result of exposure to certain chemicals (including herbicides and pesticides), chemotherapy drugs (such as etoposide and a class of drugs known as alkylating agents) and radiation. Typically, however, a doctor is unable to pinpoint the exact cause in individual cases.

Although estimates vary, there are between 10,000 and 12,000 new cases of MDS in the U.S. annually. More than 80 percent of all MDS patients are older than 60. The National Cancer Institute projects that 13,780 men and women?7,350 men and 6,430 women?will be diagnosed with AML and that 10,200 men and women will die of the malady this year.

Scientific American spoke with Bart Scott, a medical oncologist specializing in the treatment of patients with MDS, about syndrome's progression to AML, who is most at risk for this cancer and whether there are any promising treatments on the horizon. Scott is also director of hematology and hematologic malignancies at the Seattle Cancer Care Alliance and an assistant member of the Fred Hutchinson Cancer Research Center's clinical research division.

[An edited transcript of the interview follows.]

What is the typical trajectory for this form of cancer?
The trajectory of myelodysplastic syndrome is highly dependent upon two factors?the bone marrow myeloblast count and the cytogenetics. [A myeloblast is an immature blood cell that will eventually develop into a type of white blood cell.] The higher the bone marrow myeloblast count is at time of diagnosis the more likely a patient is to progress to acute myeloid leukemia. In general, the more abnormal the cytogenetics [a cell's hereditary and functionalm characteristics] are the more likely a patient is to progress to AML, but there are certain abnormalities that have a good prognosis.

Who are the typical victims of this form of leukemia?
The median age of diagnosis of MDS is 72, it is slightly more common in men than women, and there is a correlation between incidence and age. I would say that Ephron's course does seem consistent with MDS progression to AML.

What are the risk factors for this cancer?
They are based on increasing age as well as certain environmental exposures like pesticides and herbicides. This is not casual contact?we are talking about prolonged, persistent exposure. The amount of exposure required to cause the disease is unknown, however.

Given that Ephron lived most of her life in New York City, whose residents are not typically exposed to inordinately large amounts of pesticides or herbicides, what might account for her condition?
Some researchers have tried to understand MDS in terms of clustering, although there is very little clustering data available. The idea is to understand whether MDS tends to cluster in areas of higher exposure to certain toxic agents. In 2007 Xiaomei Ma [an associate professor of epidemiology the Yale School of Public Health] and a team of researchers published a paper in Leukemia Research regarding this phenomenon. They found that cases of MDS in Connecticut were clustered near the western border. In general, clustering supports the idea that environmental exposure is contributory to the development of a disease. This is the only paper that I know of that has demonstrated clustering in MDS.

We are doing a similar study in the state of Washington. Hanford Site is a nuclear production complex near the Tri-Cities area in southeastern Washington [encompassing Kennewick, Pasco and Richland]. We are looking to see if there is clustering in the Tri-Cities area. But these studies are difficult given the mobility of the area's population, unknown exposure time and any delay in the development of MDS after exposure.

What is the usual treatment?
There are three FDA approved treatments. One is azacitidine, approved by the FDA in 2004 and marketed as Vidaza. Decitabine, sold as Dacogen and approved in 2010 to treat MDS, is another option. [The FDA's oncologic drugs advisory panel in February, however, recommended against the approval of Dacogen to treat older patients with AML. The drug's maker wants FDA approval to use Dacogen in AML patients 65 years and older and who are not considered good candidates for high-dose chemotherapy as an initial treatment for AML.] The third is lenalidomide, also known as Revlimid and introduced in 2004.

However, the only curative treatment is stem cell transplantation. Stem cells are infused just like a blood transfusion. Sources of stem cells include cord blood cells, peripheral blood mobilized stem cells or bone marrow. Success depends on the stage of disease. The one-year treatment related mortality is approximately 20 percent. If patients are transplanted in an early stage of the disease, we have a success rate of 80 percent.

Are there any promising treatments in late-stage testing?
Yes, there are several drugs being investigated in phase II and phase III trials. We currently have a phase III trial open with a drug called rigosertib for patients who have failed prior treatment with azacitidine or decitabine, which are known as demethylating agents. The proposed mechanism of action for these drugs is that they alter gene expression profiles in the cancer cells and increase their susceptibility to death. Rigosertib is a cell cycle inhibitor and would prevent the cancer cells from growing and induce direct damage to the cancer cells, causing their death.

Source: http://rss.sciam.com/click.phdo?i=190fb7b8386e76050f747241b17e0dea

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GreenCartoons: RT @j_zimms: Texas GOP's official position: "Brain thoughts are for homogays" http://t.co/XKtj53u7

Sorry, Readability was unable to parse this page for content.

Source: http://twitter.com/GreenCartoons/statuses/218783817715036162

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UNC's Barnes has to wait, but all's golden at NBA draft

The Ames, Iowa, native, ranked in the top-five of most mock drafts heading into Thursday night's real deal on the NBA big stage, had to watch six players get their names plastered to the Prudential Center big board before his turn came.

He said he didn't mind the wait. Barnes was very composed and kept it together. The audience reaction was low-key.

"I'm just truly blessed," the 6-8 small forward out of the University of North Carolina said after getting selected by the Golden State Warriors with the seventh pick of the first round. "I don't really have a lot of words right now other than that."

When the Ames High School graduate finally heard his name called by NBA Commissioner David Stern, he bear-hugged his mother, Shirley, and sister Jourdan-Ashle, 13. The women couldn't stop smiling.

"He was calm, he was calm. I think I was pretty composed, as well," his mother said. "But really, just overjoyed. He's just happy to be a Warrior and just happy to actually be a league player now."

After fastening his Warriors' hat, there was only one thing left to worry about for Barnes.

"The biggest thing I was thinking was, 'Don't trip,'" said Barnes, decked out in a conservative yet slick grey suit. "I was just a little nervous and excited that I got picked."

Barnes needed a couple deep breathes after shaking Stern's hand but walked off the stage with a wide, bright smile and a shiny gold and blue Warriors hat to go with it, and was directed straight over to be interviewed on ESPN.

To everyone who congratulated him he said, "Thank you."

He was led through the tunnels to the NBA Entertainment suite for more interviews for at least 30 minutes, then back out to do an interview with Sirius Radio. The big smile never left his face as he took it all in.

North Carolina coach Roy Williams sat with Barnes' mom and sister and said his former Tar Heel star "is going to be a big-time basketball player in the NBA for many years."

"It's a fantastic night for the whole family," Williams said. "He had a great following in Ames, Iowa (where he led Ames High School to a 53-0 record and two state title between 2009-10). He had a great following at Chapel Hill. Harrison's an incredible young man."

Barnes averaged 15.7 and 17.1 points in his two seasons at UNC, becoming one of six Tar Heels to average at least 15 points as a freshman and sophomore.

"It was his goal to be in the NBA, so to have that come to fruition now is special," his mom said.

Barnes was one of 14 players selected to participate in the draft ceremonies ? and enjoy a lunch with Stern at The Westin Hotel in Times Square earlier Thursday, a sure sign of the potential most NBA experts saw in Barnes.

"He can play two positions for (Golden State), he can rebound the basketball. But the best thing he does is, he scores," Williams said. "I've never seen an NBA team that didn't need people who could score. Harrison is a great pick for them."

Barnes had a group of 26 supporting him draft night, including aunts, uncles and cousins who watched him and UNC teammates Kendall Marshall, John Henson and Tyler Zeller follow as first-round selections.

Marshall was taken at No. 13 by the Phoenix Suns, Henson went next to the Milwaukee Bucks and Zeller was taken by the Dallas Mavericks with the 17th pick, with his rights then traded to the Cleveland Cavaliers.

Barnes has never been to the Bay Area but said he looks forward to heading there Friday and starting his career with the Warriors.

"It's a very first-class organization," Barnes said. "I can't wait to get out there and play for them.

"Whatever my ceiling is, I'm definitely going to try to reach it."

Source: http://rssfeeds.usatoday.com/~r/UsatodaycomNba-TopStories/~3/hdWE30dLTXQ/1

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When Harry Met Sally: When Romantic Comedies Were Actually Fun and Smart [Video]

If you have never seen this movie, you must. Not because the brilliant Nora Ephron—the movie's screenwriter—passed away yesterday, but because it's a brilliant simple movie. A funny, clever, sometimes poignant, every time spot on look at relationships. A romantic comedy that is actually good cinema, not just the candied crap cakes made out of canned pink goo that populate movie theater nowadays. More »

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Exclusive: Saudi readies oil line to counter Iran Hormuz threat

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Microsoft attack puts spotlight on Greek tensions

ATHENS (Reuters) - Gunmen driving a van packed with gas canisters firebombed the Athens headquarters of Microsoft on Wednesday, underscoring the threat of instability as Greece asks for more time and less hardship in cutting its crippling debt.

Fire gutted the ground floor of the blue four-storey HQ of the U.S. software giant, blackening its walls with flames, on the eve of yet another European summit seeking a solution to a regional debt crisis first unleashed by Greece.

At least two attackers were involved in the sophisticated assault at 4.45 a.m. (0145 GMT) in Maroussi, a northern suburb of the sprawling Greek capital, police said.

Brandishing pistols and an automatic rifle, they kept security guards at bay and set fire to the van carrying three gas canisters and five cans of gasoline. No one was hurt in the early morning assault.

There was no immediate claim of responsibility and police said it was too early to say who was to blame. Suspicion, however, fell on left-wing militants, who have a long and violent history in Greece. Anti-terrorist units were investigating the incident.

Since the end of a military dictatorship in 1974, Greece has been scarred by political violence and assassination, much of it carried out by the militant November 17 group, named after a student uprising which was bloodily suppressed by the army.

Authorities have dismantled the group, whose victims included the CIA station chief in Athens, but splinter organizations committed to the same radical left-wing or anarchist ideals remain active.

Social tensions are rising in Greece over the harsh terms of an international bailout saving the country from bankruptcy but only at the cost of deep economic suffering.

Branches of Macdonald's, Citi and Starbucks in Athens have been set on fire by protesters and militants in the past using petrol bombs or gas canisters.

The attacks usually take place at night and there have rarely been injuries, but three bank staff suffocated in May 2010 when protesters set their branch on fire during a protest march in central Athens.

The assault on Microsoft is a new headache for big multi-nationals in Athens already considering quitting the debt-ridden country because of unpaid bills, falling revenues and the prospect that Greece might be forced to leave the euro.

"They entered the office in a van ... in an effort to burn the whole place down," Ernst-Jan Stigter, general manager of Microsoft's Greek unit, told reporters on Wednesday. "We're grateful there were no injuries and all our crew is safe."

The fire department estimated the damage at about 60,000 euros ($75,000). Staff were told not to come to work.

Contacted by Reuters, Citibank, Coca-Cola and pharmaceuticals giant GlaxoSmithKline said they had no immediate plans to step up security, which has already been tightened after violent protests seen previously in Athens.

NO QUICK RESPITE

The Greek government is unlikely to win any immediate respite from the bailout conditions at a two-day summit of EU leaders starting on Thursday whose chances of making a decisive response to the debt crisis are rated as low.

The harsh conditions attached to a 130-billion-euro ($162.12 billion) lifeline from the European Union and International Monetary Fund, on top of 110 billion in 2010, have helped condemn Greece to five years of record-breaking recession that have enraged the population.

Greeks argue that the cuts in jobs, wages and pensions demanded by lenders have spared a corrupt, tax-evading elite and heaped an unfair burden on the poorest sections of society.

The streets of Athens are scarred by repeated bouts of violent protest. Banks, fast-food chains and government ministries have been targeted in arson or bomb attacks.

Responding to huge public pressure after a June 17 election, conservative Prime Minister Antonis Samaras has called for tax cuts, extra help for the poor and jobless, a freeze on public sector lay-offs and two more years to bring Greece's deficit under control.

He will miss the two-day EU summit after undergoing eye surgery on Saturday. Government spokesman Simos Kedikoglou said the prime minister would send a letter to EU leaders calling for "a different approach".

"It will assure them that we will honour our commitments and that we want to meet the fiscal consolidation targets, a balanced budget and other targets included in the accord with our European partners," Kedikoglou told 9.84 radio.

But, he added, "Our experience over the past two years shows that the recipe has brought a rapid rise in unemployment and a deepening recession. Accordingly, they have to let us try a different approach. We are seeking room for growth."

Fast losing patience with the slow pace of reform and a litany of broken promises, the country's euro zone partners, led by paymaster Germany, are reluctant to give more leeway.

The Greek wish-list goes far beyond the "adjustments" offered by euro zone partners to make up for weeks of paralysis during two elections since May and a deeper than expected recession.

All sides have played down prospects for any meaningful progress on Greece at the summit, and Athens says it will take its case to European capitals and Washington once Samaras has recovered from surgery to repair a damaged retina.

Greece's delegation to the summit will be led by 83-year-old President Karolos Papoulias. An aide, who declined to be named, said the president would fly economy class.

($1 = 0.8019 euros)

(Additional reporting by Tatiana Fragou, Karolina Tagaris, George Georgiopoulos and Deepa Babington; Writing by Matt Robinson; editing by Barry Moody and Peter Millership)

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WI Humane Society reminds owners to keep pets cool | FOX6Now ...

Posted on: 12:56 pm, June 26, 2012, by Angelica Duria, updated on: 10:02pm, June 26, 2012

MILWAUKEE ? With forecasted temperatures in the 90s for the next few days, Humane Society officials are reminding pet owners not to forget about keeping their pets cool!?Wisconsin Humane Society officials say pets can feel the effects of the heat just as much as their owners do.

?Animals do not have the same methods of regulating their body temperatures as humans do.? Dogs actually cool themselves by panting, so one of the signs of heat stroke is excessive panting, difficulty breathing, diarrhea or throwing up,? Angela Speed with the Wisconsin Humane Society said.

Last year, a few dogs in Milwaukee died from heat stroke after being left inside a car.? With the upcoming temperatures reaching the triple digits, it would take only a few minutes for the inside of a vehicle to reach 160 degrees.

If you?re going to be walking your dog outside, officials advise keeping walks short, and heading out during the cooler parts of the day.? Inside, have a shaded place for your pet or keep a fan running, and of course, have plenty of water to keep your pup cool.

?For people who don?t have air conditioning, get a kiddie pool,? Speed said.

Certain breeds also require even more attention in the heat.

?Dogs with snub noses can?t breathe as easily as dogs with longer snouts. ?Senior animals are especially vulnerable too,? Speed said.

If your dog does start to show signs of heat stroke, don?t use cold water or ice to cool it off. Officials say that could cause your pet to go into shock.? Instead, bring the animal inside to a cool space and call the veterinarian.

Monitor the weather and hot temperatures by checking the weather section on FOX6Now.com.

Related stories:

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Successful transplant of patient-derived stem cells into mice with muscular dystrophy

ScienceDaily (June 27, 2012) ? Stem cells from patients with a rare form of muscular dystrophy have been successfully transplanted into mice affected by the same form of dystrophy, according to a new study published June 27 in Science Translational Medicine.

For the first time, scientists have turned muscular dystrophy patients' fibroblast cells (common cells found in connective tissue) into stem cells and then differentiated them into muscle precursor cells. The muscle cells were then genetically modified and transplanted into mice.

The new technique, which was initially developed at the San Raffaele Scientific Institute of Milan and completed at UCL, could be used in the future for treating patients with limb-girdle muscular dystrophy (a rare form in which the shoulders and hips are primarily affected) and, possibly, other forms of muscular dystrophies.

Muscular dystrophies are genetic disorders primarily affecting skeletal muscle that result in greatly impaired mobility and, in severe cases, respiratory and cardiac dysfunction. There is no effective treatment, although several new approaches are entering clinical testing including cell therapy.

In this study, scientists focused on genetically modifying a type of cell called a mesoangioblast, which is derived from blood vessels and has been shown in previous studies to have potential in treating muscular dystrophy. However, the authors found that they could not get a sufficient number of mesoangioblasts from patients with limb-girdle muscular dystrophy because the muscles of the patients were depleted of these cells.

Instead, scientists in this study "reprogrammed" adult cells from patients with limb-girdle muscular dystrophy into stem cells and were able to induce them to differentiate into mesoangioblast-like cells. After these 'progenitor' cells were genetically corrected using a viral vector, they were injected into mice with muscular dystrophy, where they homed-in on damaged muscle fibres.

The researchers also showed that when the same muscle progenitor cells were derived from mice the transplanted cells strengthened damaged muscle and enabled the dystrophic mice to run for longer on a treadmill than dystrophic mice that did not receive the cells.

Dr Francesco Saverio Tedesco, UCL Cell & Developmental Biology, who led the study, said: "This is a major proof of concept study. We have shown that we can bypass the limited amount of patients' muscle stem cells using induced pluripotent stem cells and then produce unlimited numbers of genetically corrected progenitor cells.

"This technique may be useful in the future for treating limb-girdle muscular dystrophy and perhaps other forms of muscular dystrophy."

Professor Giulio Cossu, another UCL author, said: "This procedure is very promising, but it will need to be strenuously validated before it can be translated into a clinical setting, also considering that clinical safety for these "reprogrammed" stem cells has not yet been demonstrated for any disease."

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Story Source:

The above story is reprinted from materials provided by University College London, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Francesco Saverio Tedesco, Mattia F. M. Gerli, Laura Perani, Sara Benedetti, Federica Ungaro, Marco Cassano, Stefania Antonini, Enrico Tagliafico, Valentina Artusi, Emanuela Longa, Rossana Tonlorenzi, Martina Ragazzi, Giorgia Calderazzi, Hidetoshi Hoshiya, Ornella Cappellari, Marina Mora, Benedikt Schoser, Peter Schneiderat, Mitsuo Oshimura, Roberto Bottinelli, Maurilio Sampaolesi, Yvan Torrente, Vania Broccoli, and Giulio Cossu. Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy. Sci Transl Med, 27 June 2012 DOI: 10.1126/scitranslmed.3003541

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Tips That Make Purchasing Auto Insurance From Car Insurance ...

Selecting the right auto insurance company or plan can be an exhausting and overwhelming experience. With so many different options to choose from, it?s no wonder that so many people don?t know where to start. This article contains a number of tips on how to find the right auto insurance plan and company for you.

Before you call your insurance company to change your car insurance policy, remember to check with your financier. Many auto loans come with certain insurance requirements. It is all too easy to overlook these requirements when you go bargain-hunting. If you do, an insurance claim may end up landing you in hot water with the financier holding the note on your car.

Pay for your auto insurance coverage in one payment up front. When you pay in full you will not be charged interest charges as you would if you were paying monthly. This means some companies also offer you a discount if your coverage is paid for ahead of time. Monthly payments can be convenient, but they may not be as affordable as you would like.

Be aware of your annual mileage when speaking with an agent. You?ll be amazed at how much of a difference there is between a person who rarely drives as to someone who commutes daily over long distances. So before you go speak with a representative, make sure you have an estimate of how much you drive per year.

Installing anti-theft systems in your car can save you significant money on your car insurance. Regardless of their actual effectiveness, alarms and tracking devices deter thieves and insurance companies acknowledge that fact by reducing premiums. Remember that anti-theft equipment is a one-time expense, but the value of an insurance discount will continue to grow over time.

If you are a person who has had car insurance for years but never had an accident then an insurance company who offers vanishing deductibles may be perfect for you. If you are not getting in accidents then you should be rewarded, and this kind of program offers you a reward.

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Go directly to the websites of insurance companies such as GEICO or Allstate to get quotes for auto insurance coverage. These companies are not usually represented by the online insurance aggregator sites, but you can still request quotes online for no charge and have an estimate for auto insurance coverage in about 10 minutes.

Think about becoming a member of an automobile club. If your car is a considered to be a classic or if there is another automobile club that would fit your unique circumstances, find out more information about joining. Most clubs offer their member?s insurance coverage that is less expensive than what they are currently paying.

Before you decide to purchase any auto insurance policy, one of the first things you should do is calculate your total mileage. Some people do not drive their vehicles that often, and they may be privy to certain discounts if they only use their automobiles for work use or other limited uses. Driving less means you are less of a risk.

Reduce the miles you drive, and make sure your auto insurance company knows about it. Most insurance companies offer a discount for drivers who use their car for less than 7,500 miles a year. What your auto insurer doesn?t know, however, can?t be applied for a discount, so be sure to show them your mileage each year.

When shopping for a new car, be sure to check with your insurance company for any unexpected rate changes. You may be surprised at how cheap or expensive some cars may be due to unforeseen criteria. Certain safety features may bring the cost of one car down, while certain other cars with safety risks may bring the cost up.

Keeping up with the times is a great way to save money on your auto insurance. Most insurance companies have electronic payment plans set up via their websites. If you use these and make your payments on time, you will be able to save some money. There?s nothing wrong with the old-fashioned way, but you can save some cash by making e-payments.

Check both the crash rating and the theft rating of any new car you are interested in purchasing. Car insurance companies charge more for policies on cars they feel are at a higher risk of being stolen, or that have a bad crash rating compared to other cars with much better ratings.

You may want to consider taking the superior driving test. By taking this test, car insurance companies will see that you have gone the extra mile in order to be a safe driver and will be less likely to get into an accident. This will make car insurance rates more affordable.

Add an anti-theft device to your car, either in the form of an alarm or simply a locking steering wheel bar. Most car insurance companies offer significant discounts for cars that have anti-theft devices. The cost of replacing your car after theft is a significant part of your auto insurance premium, so reducing that risk reduces your premiums.

Lower your car insurance premiums by taking a safe driver class. Many car insurance companies will offer a discount if you can provide proof of completion of a safety driving class. Taking, and passing, such a class gives the insurance company a good indication that you take your driving skills seriously and are a safe bet.

When you are looking for car insurance, try to purchase it online. Many car insurance companies tend to offer a reduction by filling out an application online. This is because most of the application process this way is automated so they do not have to spend money on processing it.

If you are trying to save on your auto insurance, increasing your deductible will give you the best savings. Most car insurance companies will charge a higher premium to the customer for the luxury of having a lower insurance deductible. If you choose a higher deductible, this will mean that you will pay higher out-of-pocket costs if you are involved in a car accident or if you need to file an insurance claim.

When you are checking rates with different car insurance companies, make sure your information is consistent with every quote you get. This way you can be sure you are getting the best quotes possible with each company you get quotes from. Then, you can accurately choose the company with the best rates.

If you can afford it, try to pay your car insurance in full. By making monthly payments, interest will keep adding on, and in the long run, you will end up paying more. Some car insurance companies even give their customers a discount when they pay their car insurance in full.

One way to keep your car insurance costs low is by not buying a sports car. Insurance companies charge higher rates for sporty vehicles since they have higher horsepower, tend to be driven by younger, riskier drivers and are notorious for moving at high speeds. Sticking with a modest, mid-size vehicle may not be much fun, but it can help keep your car insurance rates affordable.

Lower the mileage that you put on your car every year. The car insurance companies all take into account the number of miles that you annually drive, and they factor that into your premium. If you are able to decrease this mileage, you may very well get a reduction in your rates.

As the beginning of this article stated, choosing the right auto insurance company or plan is an extremely difficult decision. However, if you have a good sense of where to look and what information you need, the process becomes much easier. Use this article to help you select your auto insurance.

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Video: Will taxpayers pay for Sandusky lawsuits?

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Obama prepping thousands of lawyers for election

OLYMPIA, Wash. (AP) ? President Barack Obama's campaign has recruited a legion of lawyers to be on standby for this year's election as legal disputes surrounding the voting process escalate.

Thousands of attorneys and support staffers have agreed to aid in the effort, providing a mass of legal support that appears to be unrivaled by Republicans or precedent. Obama's campaign says it is particularly concerned about the implementation of new voter ID laws across the country, the possibility of anti-fraud activists challenging legitimate voters and the handling of voter registrations in the most competitive states.

Republicans are building their own legal teams for the election. They say they're focused on preventing fraud ? making sure people don't vote unless they're eligible ? rather than turning away qualified voters.

Since the disputed 2000 presidential election, both parties have increasingly concentrated on building legal teams ? including high-priced lawyers who are well-known in political circles ? for the Election Day run-up. The Bush-Gore election demonstrated to both sides the importance of every vote and the fact that the rules for voting and counting might actually determine the outcome. The Florida count in 2000 was decided by just 537 votes and ultimately landed in the Supreme Court.

This year in that state alone, Obama and his Democratic allies are poised to have thousands of lawyers ready for the election and hope to have more than the 5,800 attorneys available four years ago. That figure was nearly twice the 3,200 lawyers the Democrats had at their disposal in 2004.

Romney has been organizing his own legal help for the election. Campaign attorney Ben Ginsberg did not provide numbers but said the campaign has been gratified by the "overwhelming number of attorneys who have volunteered to assist."

"We will have enough lawyers to handle all situations that arise," he said.

The GOP doesn't necessarily need to have a numerical counterweight to Obama's attorneys; the 2000 election showed that experienced, connected lawyers on either side can be effective in court.

Former White House counsel Robert Bauer, who is organizing the Obama campaign's legal deployment, said there is great concern this year because he believes GOP leaders around the county have pursued new laws to impede the right to vote.

"The Republican Party and their allies have mapped out their vote suppression campaign as a response to our success in 2008 with grass-roots organization and successful turnout," Bauer said. "This is their response to defeat: changing the rules of participation so that fewer participate."

Several states with Republican leaders have recently pursued changes that could make voting more difficult, including key states such as Florida and Ohio, despite objections from voting rights groups that believe that the laws could suppress votes from low-income and minority blocs.

Republicans dispute that the laws are political, pointing to cases of election fraud and arguing that measures like those requiring voters to show identification are simply common sense.

Independent from the Romney team, a conservative group is prepping an Election Day team of its own to combat possible fraud.

Catherine Engelbrecht, president and founder of True the Vote, said the organization hopes to train and mobilize up to one million volunteers this year, many of them to serve poll watchers. One of the group's main initiatives is to "aggressively pursue fraud reports."

"Being a poll watcher is an age-old tradition and we're fortunate that so many volunteers are ready and willing to take a day off, learn what they need to know and help out at the polls," Engelbrecht said. True the Vote already has thousands signed up to help and had 500 trained election workers monitoring the Wisconsin recall vote earlier this month.

"They serve as volunteer guardians of the republic, to ensure that procedures at the polls are in keeping with state law," she said.

It's one of the efforts that have Obama's team fretting. The Democrats fear that anti-fraud activity could get out of hand, with vigilante poll watchers targeting and intimidating voters who may not know their rights.

"We will have the strategy and the resources to address the threat and protect the voter," Bauer said.

The Obama-aligned attorneys, most of whom are not election experts by trade, undergo training and have materials to show them how to help at the polls on Election Day.

Charles Lichtman, who is helping advise the effort in Florida this year after leading it in the last two cycles, first created the Florida Democratic Lawyers Council after the 2000 election, vowing that there would never be a repeat of that disputed vote. He contends Democrat Al Gore would have won the presidency over Republican George W. Bush if a similar legal infrastructure had been in place then.

Lichtman's efforts have since been replicated for other states. He said that is vital to provide voter protection.

"My experience has been that, in every election, the other side has taken drastic measures to try to suppress the vote," Lichtman said. The volunteer organization has not been involved in the 2012 legal disputes so far, though they are monitoring the developments.

Four years ago, the teams of lawyers organized by Obama and Republican candidate John McCain in 2008 went largely unused since the election wasn't very close.

But this year may be different given all the changes to voting laws ? and the closeness of the race in recent polling.

The states with the strictest ID laws require voters to show photo identification before casting ballots. If they don't have proper identification or fail to bring it, they can cast a provisional ballot but must later go to meet with state elections administrators to sort things out before the ballot is counted.

Voting groups see a variety of potential problems, such as how voters are informed of the rule changes, how poll workers handle voters who fail to bring IDs and whether voters are provided adequate notice of the steps they need to take after casting an absentee ballot.

About 30 states have some form of an ID law, with varying methods of implementation.

Legal challenges typically start coming in the weeks before the election, but "litigation has started coming sooner and more vociferously" this year, says Edward Foley, an elections law expert with Ohio State University. That includes lawsuits surrounding Florida's plan to purge ineligible voters from the rolls.

Foley said. "We're in an era of increased litigiousness over the voting process."

He said lawsuits after Election Day may occur only if votes in a battleground state are within the "margin of litigation." That would probably be a difference of just hundreds of votes, a result that would be rare.

___

Associated Press writer Mike Baker can be reached on Facebook: http://on.fb.me/HiPpEV

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Information on energy efficient windows - Double glazing windows ...

How can we benefit from double glazing? Double glazing helps you in numerous ways. It not only facilitates conserving energy, but it also retains heat and cold by acting as an insulator, reduces noise pollution, gives security and helps decrease condensation. What are the alternatives in case Double Glazing windows are inappropriate for my house?

A substitute for double glazing windows is secondary glazing. It works in a way that you fit a second glass pane in your existing windows. It's not as cost and energy efficient as double glazing ones, but it does allow you to save $ 85 a year on your heating bills and saves the environment by holding back 460 kg of carbon dioxide emissions.

Will I reduce my electricity bills by using Double gazing windows? Double glazing windows have a life of about 20 years, which implies that you get to save $ 3,300 over the time period. In case of replacing all the single glazed windows at your house with double gazing ones, you'll decrease your heating bill by $ 165. Not only this, you will also save the environment by holding back 680 kg of carbon dioxide secretions.

uPVC: What is it?

It is abbreviation for un-plasticized polyvinyl chloride. If you are looking for a lighter-on-the-pocket option for double glazing windows, uPVC would be an ideal material for you. It is the cheapest raw material used for double glazing and is also one of the most energy efficient options. They also require little maintenance with a soft wet cloth doing the job pretty well.

Can we use timber double glazing instead?

There are many options to choose from when deciding which material to use for your double glazing windows. For example there's wood and aluminum apart from uPVC. If you use timber, then that would be a greener decision because timber is a naturally renewable material. Moreover, it's much more pleasant to look at when compared to uPVC and hence many people prefer timber instead of the latter one. However, it needs proper maintenance to last for a long time.

What is WER?

WER stands for Window Energy Rating. This scheme is handled by the British Fenestration Rating Council (BFRC). Window dealers show the energy efficiency of their windows by using this scheme and rating it from A to G. In order to conform to the British regulations, the required minimum rating is C.

Is it absolutely important to get A-rated Windows?

The ranks A, B and C don't really have much of a difference in energy efficiency. Buying an A-rated window instead of B-rated one or getting a B-rated window instead of a C rated one would save you around 6.5 percent of your electricity bill. Hopefully, this guide would answer some of your questions regarding double glazing and help you sort your relevant problems.

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Being spread for too long a time can affect the taste ... - China tea sets

? posted on Monday, June 25th, 2012 at 2:07 am by admin

Being spread for too long a time can affect the taste, the color and the tea dregs of organic green tea.?? To improve the sleep state, to ensure that the sleep time. The ? work environment and the best living room colors green, blue, cool colors, it makes emotional stable less prone to impulse. Drink tea the best beauty regimen. Sometimes can not help the temptation of food, food plot, angry, constipation, gastrointestinal tract, excessive intake of fats, obesity and other problems one after another to find you. How detoxifies Cellulite diet? Chinese medicine believes that tea detoxifies Cellulite weight loss goals can be achieved, and no side effects and nutrition.
organic green tea needs to be de-enzymed under high temperature. So, which tea is best Fat Reducer? Green tea: candy, fried foods, too much green tea: candy, fried foods too much, causing lit the fire of the body due to eating too much candy, chocolate or fried foods, frothy green tea to lower drop body gathered in anger. In addition, green tea also has the eyesight, it is particularly suitable for the daily consumption of computer users. Methods: the bubble of green tea is very simple, just how many green tea dry put the cup and then pour in the water to soak a few minutes on it.
Cassia seed tea: Cassia seed tea: diet cause constipation diet of the people, because the diet caused constipation, it is recommended to drink cassia seed tea for detoxification. Diet weight loss process, will result in the accumulation of food in the small intestinal, Being spread over ten hours may ruin the aroma of newly-collected organic green tea leaves.? and thus the number of bowel movements decreased due to reduced food intake. This case will cause the stool for a long time accumulation of the body, toxins accumulation time longer. Drink Cassia seed tea can promote intestinal peristalsis, Liver eyesight, diuresis, catharsis.
Hawthorn Tea: Tea Hawthorn: meat is more for more meat in the diet, the stomach to digest meat fiber addition, the relatively large amount of fat contained in meat. In this case drink any tea detoxification need to promote digestion and to remove grease two major purposes. In this aspect, the drink hawthorn tea is a good choice. Method: Prepare 10 g of hawthorn, and then add water to cook into the juice taking, you can greatly reduce the stomach to digest the burden, eliminating the intake of fat from meat and phlegm at the same time, drain away the waste to stay in the body. To de-enzyme organic green tea leaves, the temperature should be high at the beginning and then be lowered.
Pu?er tea: food plot, indigestion, Pu?er tea: food plot, indigestion, excessive intake of fat, the first lunar month festival, the relative excess food intake, easily lead to stomach the food plot, no time to digest food. Body from the food intake of fat and sugar than usual, increased significantly, if not as soon as these two substances excreted induced gastrointestinal discomfort, but will cause the fat situation. Methods: The right amount of tea leaves with the discharge of five green tea drinking, can help digestion and taken away by the dependence of the fat in the gastrointestinal tract, help lose weight Cellulite. The condition of dewatering in organic green tea gardens is relatively convenient.

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sidasaberayuda ? Blog Archive ? Car Insurance coverage Prices

5 Quick Ways to Save With Auto Insurance Quotes

If you plan on driving on the main roads of America, all states are going to require that you have some sort of auto insurance. Without that insurance, count on some heavy fines if you get pulled over. Whether you?re looking to switch insurance companies or you?re looking to insure your brand new car, here are some quick saving tips you should know about before asking for an auto insurance quote:

Always Comparison Shop

Don?t just settle for the first auto insurance company you come across. Instead, be sure to compare and get more than one auto insurance quote. The more quotes you get, the easier it will be for you to see how the prices vary on the market.

Be Accurate

With every auto insurance quote you get, always be exact with your answers.

Don?t lie about your driver?s record, the make and model of your car or your age. This can all come back to bite you because all insurance companies will perform a background check of some sort to get accurate information. By being accurate, you can be assured you?re receiving an exact quote.

Watch the Deductibles

Are background check you tight on a budget? If so, consider playing around with the deductibles and comprehensive numbers. The higher these numbers are, the lower your auto insurance quote will be. Most of the time, your deductibles will be around 30 to 60 percent of your overall quote. Most quote applications online allow you to play around with these numbers.

Know your Discounts

The moment you receive an auto insurance quote, don?t think that this is your quote set in stone.

Keep in mind that many insurance companies offer discounts for good drivers, senior citizens and those that have multiple policies with their company. So, if you have a policy with the same company for your boat, home and car, you can count on a small discount.

More Ways to Save

An auto insurance quote will have many other features that you didn?t even know about. This could include tow assistance, roadside help and even rental car insurance. Ask yourself if you really need these premium features. The more features you take off, the more you?ll be able to save.

To get an exact auto insurance quote online, start using one of the many reputable car insurance shopping engines on the Internet.

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Texas' Josh Hamilton to be focus of biopic

Hamilton on film

Josh Hamilton's life reads like a movie script and, sure enough, a film about the Texas Rangers slugger is in the planning stages.

Hamilton has given rights to producer Basil Iwanyk and Thunder Road Pictures for a movie to be written and directed by Casey Affleck, the entertainment website Deadline.com reported.

Hamilton, of course, battled back from drug and alcohol abuse to become a star with the Rangers, and he won the American League most-valuable-player award in 2010.

He's hot again this year, ranking among the AL leaders in home runs and runs batted in. On May 8, he hit four home runs in Baltimore, becoming only the 16th player in history to homer four times in a game.

Hamilton's life "is an extraordinary odyssey," one that took him from addiction and estrangement from his family "to a spectacular rebirth of his life, faith, marriage and major-league career," Deadline.com quoted Iwanyk as saying.

Now the question is: Which actor could play the 31-year-old Hamilton, who is 6 feet 4 and weighs about 240 pounds?

Dickey forecast

The amazing run of knuckleball pitcher R.A. Dickey has sparked a torrent of commentary, including this query: If Dickey leads his New York Mets to the playoffs, would he still be effective in colder weather?

The theory is that knuckleball pitchers tend to lose their feel for the baseball when temperatures drop. But a glance at past knuckleballers indicates that might not be true.

Tim Wakefield was 33-36 during his career in June, according to a monthly breakdown by Baseball-Reference.com. The website lumps September and October together, and in that period Wakefield was 33-33.

Phil Niekro ("Knucksie") was 58-43 in June and 50-47 in the September/October period. Hoyt Wilhelm was 21-29 in June and 36-14 in September/October.

September can be plenty warm, of course, so that might skew the September/October figures away from the effect of cold days in October.

In any case, the World Series this year doesn't start until Oct. 24, by which time Dickey and the Mets ? if they get that far ? might have those hand warmers ready just in case.

Dickey is 11-1 with a 2.00 earned-run average and has won his last nine decisions. He's scheduled to start again Sunday against the New York Yankees.

Dickson shines

O'Koyea Dickson, a first baseman with the Dodgers' Class-A Great Lakes (Michigan) team, went two for three with a two-run home run to help the East win, 18-2, in the Midwest LeagueAll-Star game.

The San Francisco native, selected by the Dodgers in the 12th round of the first-year draft in 2011, was batting .331 with six home runs in 39 games for the Great Lakes Loons before the break.

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Chinese spacecraft docks with orbiting module

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Failure Is an Option: Does History Forecast Disaster for the United States? (Atlantic Politics Channel)

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Lichen can survive in space: Space station research sheds light on origin of life; potential for better sunscreens

ScienceDaily (June 23, 2012) ? You can freeze it, thaw it, vacuum dry it and expose it to radiation, but still life survives. ESA's research on the International Space Station is giving credibility to theories that life came from outer space -- as well as helping to create better sunscreens.

In 2008 scientists sent the suitcase-sized Expose-E experiment package to the Space Station filled with organic compounds and living organisms to test their reaction to outer space.

When astronauts venture on a spacewalk, hours are spent preparing protective suits to survive the hostile conditions. No effort was made to protect the bacteria, seeds, lichen and algae attached to the outside of the Space Station, however.

"We are exploring the limits of life," explains ESA's Ren? Demets.

Our atmosphere does a wonderful job of protecting life on Earth by absorbing harmful UV rays and keeping temperatures relatively stable.

In contrast, the space samples endured the full power of the Sun's rays. The samples were insulated somewhat by the Space Station but still had to cope with temperatures changing from -12?C to +40?C over 200 times as they orbited Earth.

The samples returned to Earth in 2009 and the results have now been published in a special issue of the journal Astrobiology.

Lichen have proven to be tough cookies -- back on Earth, some species continue to grow normally.

Ren? explains, "These organisms go into a dormant state waiting for better conditions to arrive."

The lichen have attracted interest from cosmetic companies. They can survive the full power of the Sun for 18 months, so knowing more could lead to new ingredients for sunscreen.

Living organisms surviving in open space supports the idea of 'panspermia' -- life spreading from one planet to another, or even between solar systems.

It seems possible that organisms could colonize planets by hitching rides on asteroids. ESA is probing this intriguing theory further on future Station missions with different samples.

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The above story is reprinted from materials provided by European Space Agency.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Herv? Cottin, Yuan Yong Guan, Audrey Noblet, Olivier Poch, Kafila Saiagh, M?gane Cloix, Fr?d?rique Macari, Murielle J?rome, Patrice Coll, Fran?ois Raulin, Fabien Stalport, Cyril Szopa, Maryl?ne Bertrand, Annie Chabin, Frances Westall, Didier Chaput, Ren? Demets, Andr? Brack. The PROCESS Experiment: An Astrochemistry Laboratory for Solid and Gaseous Organic Samples in Low-Earth Orbit. Astrobiology, 2012; 12 (5): 412 DOI: 10.1089/ast.2011.0773

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bsonenstein: Nothing like using our troops as propaganda for more drone strikes http://t.co/SJ9BZ1RC disgusting, via @HuffPostPol

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